体内代谢In vivo metabolism
1）药物吸收、分布、代谢与排泄特性表征 Absorption, distribution, metabolism and excretion(ADME)
2）药物体内过程及主要药动学参数 Intracorporal process of drugs and major PK parameter
3）生物利用度Bioavailability
4）生物等效性Bioequivalence
体外代谢 In vitro metabolism
1）人和动物的代谢稳定性 Species variation in metabolism
2）药物代谢相互作用 Drug-drug interactions
3）药物转运特性Drug absorption and kinetics
4）血浆蛋白结合Protein binding
5）代谢产物分析Metabolite identification, stability, and profile
